Lithium-induced Increase of Synaptosomal Uptake of Norepinephrine in Rat Brain

• 영문명: Lithium-induced Increase of Synaptosomal Uptake of Norepinephrine in Rat Brain
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Young-Wuk Cho Seung-Ho Han Chang-Ju Kim Byung-Il Min
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제1권 제2호, 127~133쪽, 전체 7쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 1997.01.01

영문 초록

Lithium remains the most widely used therapeutic agent for bipolar affective disorder, particularly mania. Although many investigators have studied the effects of lithium on abnormalities in monoamine neurotransmitter as a pathophysiological basis of affective disorder, the action mechanism of lithium ion remains still unknown. To explore the action mechanism of lithium in the brain, we examined the effects of lithium on the extrasynaptosomal concentrations of catecholamines and their metabolites. Synaptosomes were prepared from the rat forebrains and assays of catecholamines and metabolites were made using HPLC with an electrochemical detector. Lithium of 1mM decreased the extrasynaptosomal concentrations of NE from the control group of 3.07⁑1.19 to the treated group of 0.00⁑0.00 (ng/ml of synaptosomal suspension) but not that of DHPG. It can be suggested that lithium increases synaptosomal uptake of NE. Increased intraneuronal uptake of NE would decrease neurotransmission and extraneuronal metabolism of NE. Because increased brain NE metabolism and neurotransmission have been suggested as important components in the pathophysiology of bipolar affective disorder, especially mania, lithium-induced increase of intraneuronal NE uptake can be suspected as an action mechanism of therapeutic effect of lithium in manic patient, possibly in bipolar affective disorder.

키워드

Lithium Norepinephrine HPLC Synaptosome