빈크리스틴에 의해 유발된 말초신경병증 실험동물 모델 연구에 대한 고찰

• 영문명: A Review of Experimental Animal Models of Vincristine-Induced Peripheral Neuropathy
• 발행기관: 한국동물보건학회
• 저자명: 윤서연(Seo-Yeon Yoon) 신힘차(Him Cha Shin) 김예빈(Ye Bin Kim)
• 간행물 정보: 『한국동물보건학회지』4권 2호, 189~203쪽, 전체 15쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2025.06.30

국문 초록

Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting adverse effect of cancer therapy. The pathophysiology of CIPN is highly complex and its mechanisms are not yet fully elucidated, making rodent animal models essential tools for mechanistic studies. Notably, as vincristine-induced peripheral neuropathy (VIPN) presents with clinical similarity in humans and companion animals, mechanistic studies using experimental animals can provide key information applicable to both human and veterinary medicine. Therefore, this review examines various protocols for establishing VIPN models in rodents and, furthermore, comprehensively discusses the behavioral, electrophysiological and histological methods commonly applied for the evaluation of CIPN models in general. In conclusion, refining these animal models and strengthening preclinical-to-clinical translational research is crucial for developing effective therapies for both human and animal patients.

목차

1. 서론

2. 본론

3. 결론

References

키워드

Chemotherapy Peripheral neuropathy Vincristine Animal model