새로운 방향족 에스테르계 가소제 합성 및 내분비계 장애성 시험

• 영문명: Synthesis of New Aromatic Ester Plasticizers and Their Endocrine Disrupting Screening
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 유경호(Yoo KyungHo) 류재천(Ryu JaeChun)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제24권 제3호, 211~218쪽, 전체 8쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2007.09.30

영문 초록

Based on the Benzoflex (Vesicol Chemical Co.) as PVC plasticizer substituents for Di-n-octyl phthalate (DOP), a series of new aromatic carboxylic acid ester compounds were designed as plasticizers, synthesized, and screened for the endocrine disrupting activity. 2-Hydroxybenzoic acid (1) and 2-methoxybenzoic acid (2) as the commercially available starting materials were reacted with diethylene glycol (3) in the presence of p-toluenesulfonic acid using Dean-Stark column to give diethylene glycol di-(2-hydroxy)benzoate (4, KH01) and diethylene glycol di-(2-methoxy)benzoate (5, KH02), respectively. And diethylene glycol di-(3-pyridinyl) ester (7, KH03) and dipropylene glycol di-(3-pyridinyl) ester (9, KH04) were obtained in high yields by treatment of nicotinoyl chloride (6) with diethylene glycol (3) and dipropylene glycol (8) in the presence of triethylamine as a base. To determine the estrogenic disrupting effect of new synthetic phthalate analogues, E-screen assay method was used. Of these compounds, 4 (KH01) was found to be compound without endocrine disrupting effect.

키워드

plasticizers aromatic esters endocrine disrupting effect