In Vitro에서 광증감제에 의한 광학적 영향에 관한 연구

• 영문명: A Study on the Optical Influence by Photosensitizer in Vitro
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 김기준(Kim KiJun) 성기천(Sung KiChun)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제22권 제2호, 182~190쪽, 전체 9쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 2005.06.30

영문 초록

The propagation of light radiation within tissues is an important problem that confronts the dosimetry of therapeutic laser delivery and the development of diagnostic spectroscopy. In the clinical application of photodynamic therapy(PDT) and in photobiology, the photon deposition within a tissue determines the spatial distribution of photochemical reactions. Scattered light is measured as a function of the distance (r) between the axis of the incident beam and the detection spot. Consequently, knowledge of the photosensitizer(Chlorophyll-a) function that characterizes a phantom is important. To obtain the results of scattering coefficients({mu}s) of a turbid material from diffusion described by experimental approach. It was measured the energy fluency of photon radiation at the position of penetration depth. From fluorescence experimental method obtained the analytical expression for the scattered light as the values of (I;/Io){wavelength} vs the distance between the center of the incident beam and optical fiber in terms of the condition of in situ spectroscopy(optically thick) and real time by fluorometric measurements.

키워드

photodynamic therapy scattering coefficient photosensitizer Chlorophyll-a in situ spectroscopy