서울시내 소화기 및 호흡기 환자에서 분리한 엔테로바이러스 감염실태 및 유전형분석

• 영문명: Genotypes and Infection Status of Human Enterovirus Associated with Enteric and Respiratory Patients in Seoul, Korea
• 발행기관: 한국환경보건학회
• 저자명: 장정임(Jungim Jang) 오세아(Seah Oh) 박상훈(SangHun Park) 함희진(HeeJin Ham) 조석주(Sukju Jo) 최성민(Sungmin Choi) 강병학(Byunghak Kang) 황서연(SeoYeon Hwang) 김진석(JinSeok Kim)
• 간행물 정보: 『한국환경보건학회지』제39권 제2호, 178~186쪽, 전체 9쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2013.04.30

영문 초록

Objective: Human enteroviruses (HEVs) are a common causative agent of gastrointestinal or respiratory infections. In this study, to examine the genotypic diversity and characteristics of HEVs associated with patients in Seoul, we collected and analyzed stool and throat swab samples taken from patients with acute gastroenteritis or a common cold from 2011 to 2012. We researched the difference in genetic characteristics of HEVs from gastroenteritis and respiratory patients. Methods: For genetic analysis, we amplified the 5’-noncoding region and partial VP1 region of HEVs by RTPCR. The genotypes of HEVs were further identified based on nucleotide sequences of the VP1 region. Results: The majority of the HEV infections in Seoul occurred from June to August. The molecular characteristic assay showed that although the majority of HEVs can be propagated by a fecal-oral route, Coxsackievirus A2 (n=13, 19.4%) , A4 (n=8, 11.9%), and A5 (n=4, 6.0%) can be preferentially transmitted by a respiratory route. Conclusions: This Enterovirus surveillance system plays an important role in preparing for a severe outbreak. The genotypic characteristics of HEV may provide potentially useful data needed for epidemiological studies.

키워드

coxsackievirus gastroenteritis human enterovirus respiratory route VP1