시야 결손이 있는 뇌하수체샘종 환자에서 수술 후 시야 변화

• 영문명: Postoperative Visual Field Outcomes in Patients Showing Visual Field Defects due to Pituitary Adenoma
• 발행기관: 대한안과학회
• 저자명: 문찬희 황선철 박태관,Chan Hee Moon, MD, Sun Chul Hwang, MD, Tae Kwann Park, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume52,number6, 726~733쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2011.06.15

영문 초록

Purpose: To evaluate visual field (VF) changes in patients with pituitary adenoma after surgical treatment. Methods: The present study retrospectively evaluated 96 eyes of 48 patients with pituitary adenoma who received surgical tumor removal between July 2001 and February 2010. Preoperative and postoperative clinical data including age, tumor volume, logMAR BCVA, surgical technique (transsphenoidal surgery and transcranial surgery), static perimetry scores (mean deviation [MD], pattern standard deviation [PSD], and visual field defect [VFD] scores) were reviewed. Results: The MD (15.79%, p = 0.001) and PSD (3.98%, p = 0.003) improved postoperatively (mean postoperative follow- up period 1.85 months). Transsphenoidal surgery for tumor removal showed significant MD (26.99%, p = 0.000) and PSD (12.92%, p = 0.003) improvements. A multivariate regression analysis of the transsphenoidal surgery patient group revealed that the preoperative MD was related to the postoperative MD (Pearson = 0.762, p = 0.000), but negatively correlated to the amount of postoperative improvement in MD score (Pearson = -0.231, p = 0.046). Transcranial surgery did not significantly improve the MD (p = 0.419), PSD (p = 0.562), VFD score (p = 0.135), or logMAR BCVA (p = 0.708). Conclusions: Visual filed defects in patients with pituitary adenoma improved after neurosurgical treatment. Better postoperative visual field outcomes were achieved in patients who had smaller preoperative visual field defects. Transsphenoidal surgery significantly improved the visual field defects and visual acuity in patients with non-functioning pituitary adenoma, compared to the transcranial surgery patients. J Korean Ophthalmol Soc 2011;52(6):726-733

키워드

Mean deviation, Pattern standard deviation, Pituitary adenoma, Transcranial surgery, Transsphenoidal surgery