망막분지정맥폐쇄 황반부종에서 유리체강내 베바시주맙 주입술의 단기효과와 형태학적 분석

• 영문명: Short-term Effects of Intravitreal Bevacizumab Injection and Macular Edema Patterns in Branch Retinal Vein Occlusion
• 발행기관: 대한안과학회
• 저자명: 송영빈 박성표,Young Bin Song, MD, Sung Pyo Park, MD, PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number3, 379~385쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.03.15

영문 초록

Purpose: We attempt to distinguish the patterns of macular edema due to branch retinal vein occlusion (BRVO) and to find correlations between the 24 hour short-term and three month long-term therapeutic effects of an intravitreal bevacizumab injection. Methods: Forty-four eyes in 44 patients with macular edema due to BRVO underwent an intravitreal bevacizumab injection. Ophthalmoscopic examinations, fluorescein angiographic evaluations, and optical coherence tomography (OCT) examinations performed made before the injections, after 24 hours, and at one, two and three month follow-ups. OCT yielded three patterns of macular edema: diffuse macular edema, cystoid macular edema, and serous retinal detachment. Results: Macular edema significantly improved 24 hours after the injections. The change in central macular thickness after 24 hours had a statistically significant correlation with the three month central macular thickness (Pearson correlation, r=0.757 p=0.011). Cystoid macular edema showed better improvement than the others after 24 hours, but no differences after three months. Conclusions: OCT treatment 24 hours after an intravitreal bevacizumab injection was found to be highly correlated to the long term prognosis. It is therefore useful in determining therapy and predicting the progress of macular edema in patients with BRVO. J Korean Ophthalmol Soc 2010;51(3):379-385

키워드

24 hours follow-up, Bevacizumab, Branched retinal vein occlusion, Macular edema, Ocular coherence tomography