건성안 환자의 눈물내의 케모카인 리간드4의 농도와 눈물표면인자와의 상관관계

• 영문명: CCL4 Concentration in Tears of Dry Eye Patients and Its Correlation With Tear Surface Parameters
• 발행기관: 대한안과학회
• 저자명: 이승현 임성규 윤경철,Seung Hyun Lee, MD, Seoung Kyu Im, MD, Kyung Chul Yoon, MD. PhD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume51,number3, 313~319쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2010.03.15

영문 초록

Purpose: To investigate the expression of CCL4/MIP-1β in tears of patients with dry eye syndrome and its correlation with the tear surface parameters. Methods: Forty patients with dry eye syndrome (seven Meibomian gland dysfunction and 33 non-Meibomian gland dysfunction patients) and 25 control subjects were recruited. The concentrations of CCL4 in tears were measured using an enzyme-linked immunosorbent assay. The correlations between CCL4 levels and tear surface parameters including tear film break-up time (BUT), basal tear secretion (BST), tear clearance test (TCR), corneal sensation, keratoepitheliopathy (KEP) and conjunctival goblet cell density (GCD) were analyzed in patients with dry eye syndrome. Results: The mean levels of MIP-1β were 4.3±5.2 pg/ml in patients with dry eye syndrome and 81.6±294.3 pg/ml in control subjects (p=0.03). The mean levels in non-Meibomian gland disease patients (90.4±313.9 pg/ml) were significantly higher than those of Meibomian gland dysfunction patients (20.3±23.2 pg/ml, p=0.02). CCL4 levels correlated significantly with BST, TCR, KEP and GCD (p<0.05). Conclusions: The level of MIP-1β is elevated in tears of patients with dry eye syndrome and correlates with disease severity and tear surface parameters. J Korean Ophthalmol Soc 2010;51(3):313-319

키워드

CCL4, Chemokine, Dry eye syndrome, Tear surface parameter