원발성 안구내 림프종의 임상 양상과 진단 및 치료

• 영문명: Clinical Manifestations of Intraocular Lymphoma
• 발행기관: 대한안과학회
• 저자명: 서민희 유형곤-,Min Hee Suh, MD, Hyeong Gon Yu, MD, PhD-
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number1, 78~84쪽, 전체 7쪽
• 주제분류: 인문학 > 역사학
• 파일형태: PDF
• 발행일자: 2009.01.15

영문 초록

Purpose: To investigate the clinical features and prognosis of primary intraocular lymphoma (PIOL). Methods: A retrospective review of medical records was performed in 9 patients who were diagnosed and treated as PIOL in the Department of Ophthalmology, Seoul National University Hospital. Results: Among patients who were enrolled in the study, 14 eyes were examined. Thirteen eyes (92.9%) showed yellowish subretinal or choroidal infiltrates which is a characteristic finding of PIOL in fundus examination and fluorescein angiography. Three patients presented with ocular symptoms initially, and 5 patients later presented with central nerve system (CNS) involvement. Only 1 patient showed PIOL without CNS involvement. Among 6 patients (9 eyes) that received systemic chemotherapy or ocular irradiation, 5 patients (7 eyes, 77.8%) responded. Among those patients, 3 patients (4 eyes) showed relapse of PIOL. Five patients died during the mean follow-up period of 43.3 months, and the median survival time was 47 months. Conclusions: The most common characteristic fundus finding of PIOL is subretinal or choroidal infiltration. Ocular irradiation combined with systemic chemotherapy is the first method of treatment, although long-term prognosis is poor.

키워드

Primary central nervous system lymphoma, Primary intraocular lymphoma, Prognosis, Subretinal or choroidal infiltration, Vitreous biopsy