한방 소갈약 추출물의 혼합물에 의한 항돌연변이 효과

• 영문명: Antimutagenic Effect of the Extract Complex of Korean Anti-thirst Herb Medicines
• 발행기관: 대한약학회
• 저자명: 박건영(Kun Young Park) 정근옥(Geun Ok Jung) 이경태(Kyung Tae Lee) 최종원(Jong Won Choi) 정현주(Hyun Ju Jung) 박희준(Hee Juhn Park)
• 간행물 정보: 『약학회지』제46권 제5호 (2002년), 352~357쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.10.31

영문 초록

The three crude drugs of the Kalopanax pictus(Araliaceae) roots (K), Pueraria thunbergiana(Leguminosae) flowers (P), and the Rhus verniciflua(Anacardiaceae) heartwood (R) used for anti-thirst drugs in oriental herb medicine were extracted with MeOH, respectively, and the successive fractionation of the extract gave EtOAc extract. Certain amount ratios of the three extracts were also prepared to compare the antimutagenicity in Ames test. In N- methyl-N(-nitro-N- nitrosoguanidine (MNNG; 0.4 (g/plate)-induced test, the activities of complex mixture were observed between the highest antimutagenic activity of K extract and the lowest P extract. In aflatoxin (AFBI)-induced test, the EtOAc complex (K : p : R=1 : 1 : 3) labeled I-113 decreased the revertants of Salmonella typhimurium TA100 by 95%, which activity were highest among other extracts or complexes mixture used. Fractionation of organic solvent mostly increased the anti-mutagenicity. These trends were also observed in the antimutagenicity test of the mixture of each active component of kalopanaxsaponin A, tectorigenin and sulfuretin. These results supported that many kinds of anti-thirst herb medicine in the prescription could effectively prevent cancer disease.

키워드

anti-thirst antimutagenicity extract mixture Kalopanax pictus Pueraria thunbergiana Rhus vemiciflua.