마이크로에멀젼을 이용한 프로포폴 주사제의 개발 및 평가

• 영문명: Preparation and Evaluation of Propofol Microemulsion for Parenteral Use
• 발행기관: 대한약학회
• 저자명: 이종화(Jong Hwa Lee) 박선영(Sun Young Park) 김동우(Dong Woo Kim) 조미현(Mi Hyun Cho) 조인숙(In Suk Cho) 이계원(Gye Won Lee) 박목순(Mork Soon Park) 지웅길(Ung Kil Jee)
• 간행물 정보: 『약학회지』제46권 제5호 (2002년), 337~342쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2002.10.31

영문 초록

Propofol(2,6-diisopropyl phenol) is a phenol derivative that is chemically distinct from other intravenous serdative hypnotics. It has been extensively used as a short term anesthetic agent, because of the rapid onset and short duration of action. Propofol microemulsion system was prepared with different concentrations of ethyl oleate, Solutol(R) HS 15 and Kollidon(R) 17 PF Propofol microemulsions were studied by transmittance, viscosity, Particle size, in vitro release and Pharmacokinetics. The range of transmittance of A group with 4% ethyl oleate and that of B group with 5% ethyl oleate were 2.6-95.1 and 91.3∼94.2%, respective17: Transmittance 1∼2% decreased as concentration of Kollidon(R)17 PF was increased and increased 0.8∼3.3% when 10 times diluted with normal saline. The viscosity of A and B group were in the range of 3.9∼ 4.1 mPa ·sec and 4.4∼5.3 mPa ·sec, respectively: The particle sizes of A and B group increased as amount of Kollidon(R) 17 PF Also, release of propofol was slowly increased as the amount of Kollidon (R) 17 PF was increased. Propofol plasma concentration by 1.v injection showed 2-compartment model. Pharmacokinetics of A-5 was similar to that of commercial emulsion(POFOL).

키워드

Propofol microemulsion pharmacokinetics.