2-(4-비페닐일)부티르산의 합성

• 영문명: Facile Synthesis of 2-(4-Biphenylyl)butyric Acid
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 윤호상(Ho Sang Yun) 강병원(Byung Won Kang) 손병화(Byeng Wha Son) 정우진(Woo Jin Jung)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 137~139쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

A new method for xenbucin, which is a antihypercholesteremic agent, is described. Friedel-Crafts reaction of biphenyl with ethyl alpha-chloro-alpha-chloro-alpha(methylthio)acetate(1) afforded ethyl 2-methylthio-2(4-biphenylyl)acetate(2). Ethyl 2-(4-biphenylyl)butyric(4) was obtained by ethylation of(2) with NaH and C2H5I, folowed by desulfurization of the resultant ethyl 2-methylthio-2-4-biphenylyl)butyrate(3) with zinc dust in acetic acid. Xenbucin was synthesized by hydrolsis of (4).