생체실료로 부터 미량 디페닐히단토인의 고상추출에 사용될 흡착제의 특성

• 영문명: Characterization of Adsorbents for the Solid-Phase Extraction of Trace Diphenylhydantoin from Biological Samples
• 발행기관: 대한약학회
• 저자명: 김경례(Kyoung Rae Kim) 이경원(Kyoung Won Lee) 심원희(Weon Hee Shim)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 120~125쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

The sorption and desorption properties of four different solid adsorbents were evaluated for the trace enrichment of diphenylhydantoin from biological samples. Graphitized carbon black(GCB) gave the highest adsorption coefficient. And among the organic solvents examined, methanol gave the highest desorption coefficient. Using the GCB column, the optimum elution volume of the eluting solvent was evaluated from the breakthrough curve of diphenylhydantoin. The usefulness of GCB as the solid adsorbent was examined for the solid-phase extraction of diphenylhydantoin from serum in the concentration range of 20-50mcg/ml.