4-비페닐아세트산(펠비낙)의 합성

• 영문명: Facile Synthesis of 4-Biphenylacetic Acid (Felbinac)
• 발행기관: 대한약학회
• 저자명: 최홍대(Hong Dae Choi) 윤호상(Ho Sang Yun) 강병원(Byung Won Kang)
• 간행물 정보: 『약학회지』제36권 제2호 (1992년), 126~128쪽, 전체 3쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1992.04.29

영문 초록

A new method for felbinac, which is a potent anti-inflammatory agent, is described. Friedel-Crafts reaction of biphenyl with ethyl alpha-chloro-alpha-(methylthio)acetate(1) afforded ethyl 2-methylthio-2-(4-biphenylyl)acetate(4). Felbinac (7) was synthesized by desulfurization of compound (4) with zinc dust in acetic acid, followed by hydrolysis of the resultant ethyl 2-(4-biphenylyl)acetate(6).