실험 항암제 2-Formylpyridine Thiosemicarbazone유도체의 철 및 동착물의 합성

• 영문명: Synthesis of Iron and Copper Complexes of 2-Formylpyridine Thiosemicarbazone Derivatives, Potential Antitumor Agents
• 발행기관: 대한약학회
• 저자명: 김종윤(Jong Yoon Kim) 최보길(Bo Gil Choi) 우순형(Soon Hyung Woo)
• 간행물 정보: 『약학회지』제26권 제3호 (1982년), 181~184쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1982.09.30

영문 초록

The iron and copper chelates of 4-dimethylamino-2-formylpyridine thiosemicarbazone, one of the amine substituted derivatives at 4-C of 2-formylpyridine thiosemicarbazones which are known as the more improved potential antitumor agents, have been synthesized to make them more effective than the ligand (denoted as HL) itself. Their ligand-to-metal ratios were 2:1 and 1:1 for the iron and copper chelates, and the data along with those of elemental analysis and IR spectroscopy showed that the compositions are [FeL2].2H2SO4 and [CuL(H20)]Cl, respectively.