세균의 항생물질 내성에 관한 연구 Macrolide계 항생물질에 대한 유도 내성 Bacillus속 세균

• 영문명: Studies on the Resistance to Antibiotics in Bacteria Induced Resistance to Macrolide Antibiotics in Bacillus sp.
• 발행기관: 대한약학회
• 저자명: 최응칠(Eung Chil Choi) 김병각(Byong Kak Kim) 심미자(Mi Ja Shim) 정경수(Kyeong Soo Chung) 우정원(Jeong Won Woo) 김혜령(Hye Rung Kim) 이종길(Chong Kil Lee)
• 간행물 정보: 『약학회지』제26권 제3호 (1982년), 169~174쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1982.09.30

영문 초록

Several strains of bacteria having resistance to macrolide antibiotics were isolated. EMR-1, one of them, exhibited the induced resistance to macrolide antibiotics and this microorganism was identified as a bacterium belong to Bacillus species. The subinhibitory concentration of erythromycin or oleandomycin induced strong resistance to both erythromycin and oleandomycin themselves and to other macrolide antibiotics such as leucomycin, spiramycin and josamycin. The effective concentration of inducer, erythromycin was 0.0016~0.2mcg/ml. The inactivating enzyme of these antibiotics was not produced by EMR-1.