인삼이 백서 간약물대사효소에 미치는 효과

• 영문명: The Effect of Ginseng on Hepatic Drug Metabolizing Enzyme in Rats
• 발행기관: 대한약학회
• 저자명: 이태하(Tae Ha Lee) 김낙두(Nak Doo Kim)
• 간행물 정보: 『약학회지』제25권 제4호 (1981년), 145~151쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1981.12.30

영문 초록

The effect of ginseng methanol extract on hepatic drug metabolizing enzyme in rat was investigated. The ginseng methanol extract (100mg/kg) was administered orally to Sprague Dawley rats for 7 days and the contents of cytochrome P450 and NADPH cytochrome c reductase in liver were measured bv the method of Stanton et al. and Mazel respectively. The content of liver cytochrome P450 and NADPH cytochrome c reductase in the rats treated with ginseng methanol extract (100mg/kg) were increased by 21.9% and 16.6% respectively and their increases were statistically significant. Single i.p. injection of phenobarbital (100mg/kg) to the rats produced approximately 25% increase in cytochrome P450 content in this investigation and further stimulation was produced in the rats pretreated with ginseng methanol extract (100mg/kg). On the other hand, single i.p. injection of 95% CCl4 (0.5ml/kg) showed 29% decrease in cytochrome P450 content and 10.5% decrease in NADPH cytochrome c reductase activity. The degree of inhibition of cytochrome P450 content in the rats pretreated with ginseng methanol extract (100mg/kg) was similar to that observed in the CCl4 alone treated group, but NADPH cytochrome c reductase activity was increased by 65% in the rats pretreated with ginseng methanol extract (100mg/kg). These results suggest that ginseng is the hepatic drug metabolizing enzyme inducing agent in the rat and the effect is similar to phenobarbital.