Analysis of Pretreatment Prognostic Factors in Locally Advanced Carcinoma of the Uterine Cervix

• 발행기관: 대한방사선종양학회
• 저자명: 오도훈 (Do Hoon Oh) 하성환 (Sung Whan Ha) 이무송 (Moo Song Lee)
• 간행물 정보: 『대한방사선종양학회지』제10권 제1호, 69~76쪽, 전체 8쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 1992.06.30

국문 초록

국소진행된 자궁경부암에 있어서의 예후인자를 알아보기 위하여 1979년 3월부터 1986년 12월까지 서울대학교병원에서 근치적방사선치료를 시행받은 154명의 환자를 대상으로 후향적 분석을 시행하였다. FIGO 병기 IIIA, IIIB, IVA의 환자 수는 각각 8,134, 12명이었고 병기에 따른 5년 국소치료율을 각각 58%, 51%, 27%이었으며 5년 무병생존율은 각각 57%, 40%, 25%, 5년 생존율은 각각 67%, 51%, 33%이었다. 단변수분석에 의하면 임신 횟수, 혈색소치, 전산화단층촬영상 골반측벽 침범소견이 국소치료율에 영향을 미치는 인자이었고 임신 횟수, 혈색소치, 전산화단층촬영상의 골반측벽 침범소견과 함께 요로조영술상의 요로폐쇄증, 전산화단층촬영상의 골반측벽 침범소견 및 방광침범소견이었다. 다변량분석에 의하면 국소치료율에 영향을 미치는 인자는 없었고 무병생존율에 영향을 미치는 인자는 전산화단층촬영상의 골반임파절 비대이었으며 생존율에 영향을 미치는 인자는 원발병소의 크기였다.

영문 초록

To identify preteatment prognostic factors in locally advanced carcinoma of the uterine cervix, retrospective analysis was undertaken of 154 patients treated with curative radiation therapy at Seoul National University Hostpital from March 1979 through December 1986. According to FiGO classification. eight patients were stage IIIA, 134 were stage IIIB, and 12 were stage IVA. Five year locoregional control rate was 58%, 51%, and 27% in stage IIIA, IIIB, and IVA, respectively. Five year disease free survival was 57%, 40%, and 25% for each stage respectively. Five year overall survival was 67%, 51%, and 33% in stage IIIA, IIIB, and IVA, respectively. In univariate analysis, fewer than or equal to four of pregnancies initial hemoglobin of lower than 10g%, and pelvic sidewall invasion on CT were associated with poor locoregional control. Number of pregnancies, initial hemoglobin level. obstructive uropathy on intavenous pyelography(IVP), pelvic lymph node (LN) status on CT, and pelvic sidewall invasion on CT were significant factors in disease free survival. In terms of overall survival, pelvic sidewall invasion on CT and bladder invasion on CT were pregnostically significant. In multivariate analysis, no factor was found to affect locoregional control and pelvic LN status was a sole significant factor affecting disease free survival In terms fo overall survival. the size of primary tumor was a significant prognosticator.

키워드

Cervix cancer Stage III & IV Prognostic factor Radiation therapy