학술논문
Exercise improves muscle mitochondrial dysfunction-associated lipid profile under circadian rhythm disturbance
이용수 2
- 영문명
- 발행기관
- 대한생리학회-대한약리학회
- 저자명
- Yu Gu Dong-Hun Seong Wenduo Liu Zilin Wang Yong Whi Jeong Jae-Cheol Kim Dae Ryong Kang Rose Ji Eun Lee Jin-Ho Koh Sang Hyun Kim
- 간행물 정보
- 『The Korean Journal of Physiology & Pharmacology』제28권 제6호, 515~526쪽, 전체 12쪽
- 주제분류
- 의약학 > 의학일반
- 파일형태
- 발행일자
- 2024.11.01
4,240원
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국문 초록
We investigated whether endurance exercise training (EXT) ameliorates circadian rhythm (CR)-induced risk factors by improving skeletal muscle (SKM) mitochondrial biogenesis, reducing oxidative stress, and modulating apoptotic protein expression. We distinguished between regular and shift workers using the National Health and Nutrition Examination Survey (NHANES) and investigated the health problems caused by shift work (CR disturbance) and the potential therapeutic effects of exercise. In our animal study, 36 rats underwent 12 weeks of CR disturbance, divided into regular and irregular CR groups. These groups were further split into EXT (n = 12) and sedentary (n = 12) for an additional 8 weeks. We analyzed SKM tissue to understand the molecular changes induced by CR and EXT. NHANES data were analyzed using SAS 9.4 and Prism 8 software, while experimental animal data were analyzed using Prism 8 software. The statistical procedures used in each experiment are indicated in the figure legends. Our studies showed that CR disturbance increases dyslipidemia, alters circadian clock proteins (BMAL1, PER2), raises apoptotic protein levels, and reduces mitochondrial biogenesis in SKM. EXT improved LDL-C and HDLC levels without affecting muscle BMAL1 expression. It also enhanced mitochondrial biogenesis (AMPK, PGC-1α, Tfam, NADH-UO, COX-I), antioxidant levels (Catalase, SOD1, SOD2), and apoptotic protein (p53, Bax/Bcl2) expression or activity in SKM. We demonstrated that shift work-induced CR disturbance leads to dyslipidemia, diminished mitochondrial biogenesis, and reduced antioxidant capacity in SKM. However, EXT can counteract dyslipidemia under CR disturbance, potentially lowering the risk of cardiovascular disorders.
영문 초록
목차
INTRODUCTION
METHODS
RESULTS
DISCUSSION
REFERENCES
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