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학술논문

Inhibition of chromosomal region maintenance 1 suppresses the migration and invasion of glioma cells via inactivation of the STAT3/MMP2 signaling pathway

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영문명
발행기관
대한생리학회-대한약리학회
저자명
Qianqian Shan Shengsheng Li Qiyu Cao Chenglong Yue Mingshan Niu Xiangyu Chen Lin Shi Huan Li Shangfe
간행물 정보
『The Korean Journal of Physiology & Pharmacology』제24권 제3호, 193~201쪽, 전체 9쪽
주제분류
의약학 > 의학일반
파일형태
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발행일자
2020.05.30
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Chromosomal region maintenance 1 (CRM1) is associated with an adverse prognosis in glioma. We previously reported that CRM1 inhibition suppressed glioma cell proliferation both in vitro and in vivo. In this study, we investigated the role of CRM1 in the migration and invasion of glioma cells. S109, a novel reversible selective inhibitor of CRM1, was used to treat Human glioma U87 and U251 cells. Cell migration and invasion were evaluated by wound-healing and transwell invasion assays. The results showed that S109 significantly inhibited the migration and invasion of U87 and U251 cells. However, mutation of Cys528 in CRM1 abolished the inhibitory activity of S109 in glioma cells. Furthermore, we found that S109 treatment decreased the expression level and activity of MMP2 and reduced the level of phosphorylated STAT3 but not total STAT3. Therefore, the inhibition of migration and invasion induced by S109 may be associated with the downregulation of MMP2 activity and expression, and inactivation of the STAT3 signaling pathway. These results support our previous conclusion that inhibition of CRM1 is an attractive strategy for the treatment of glioma.

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APA

Qianqian Shan,Shengsheng Li,Qiyu Cao,Chenglong Yue,Mingshan Niu,Xiangyu Chen,Lin Shi,Huan Li,Shangfe. (2020).Inhibition of chromosomal region maintenance 1 suppresses the migration and invasion of glioma cells via inactivation of the STAT3/MMP2 signaling pathway. The Korean Journal of Physiology & Pharmacology, 24 (3), 193-201

MLA

Qianqian Shan,Shengsheng Li,Qiyu Cao,Chenglong Yue,Mingshan Niu,Xiangyu Chen,Lin Shi,Huan Li,Shangfe. "Inhibition of chromosomal region maintenance 1 suppresses the migration and invasion of glioma cells via inactivation of the STAT3/MMP2 signaling pathway." The Korean Journal of Physiology & Pharmacology, 24.3(2020): 193-201

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