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학술논문

Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes

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영문명
발행기관
대한생리학회-대한약리학회
저자명
Yo-Seob Seo In-A Cho Tae-Hyeon Kim Jae-Seek You Ji-Su Oh Gyeong-Je Lee Do Kyung Kim Jae-Sung Kim
간행물 정보
『The Korean Journal of Physiology & Pharmacology』제24권 제3호, 249~257쪽, 전체 9쪽
주제분류
의약학 > 의학일반
파일형태
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발행일자
2020.05.30
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The aim of the present study was to investigate the pathophysiological etiology of osteoarthritis that is mediated by the apoptosis of chondrocytes exposed to 25-hydroxycholesterol (25-HC), an oxysterol synthesized by the expression of cholesterol-25-hydroxylase (CH25H) under inflammatory conditions. Interleukin-1β induced the apoptosis of chondrocytes in a dose- dependent manner. Furthermore, the production of 25-HC increased in the chondrocytes treated with interleukin-1β through the expression of CH25H. 25-HC decreased the viability of chondrocytes. Chondrocytes with condensed nucleus and apoptotic populations increased by 25- HC. Moreover, the activity and expression of caspase-3 were increased by the death ligand-mediated extrinsic and mitochondria-dependent intrinsic apoptotic pathways in the chondrocytes treated with 25-HC. Finally, 25-HC induced not only caspasedependent apoptosis, but also induced proteoglycan loss in articular cartilage ex vivo cultured rat knee joints. These data indicate that 25-HC may act as a metabolic pathophysiological factor in osteoarthritis that is mediated by progressive chondrocyte death in the articular cartilage with inflammatory condition.

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APA

Yo-Seob Seo,In-A Cho,Tae-Hyeon Kim,Jae-Seek You,Ji-Su Oh,Gyeong-Je Lee,Do Kyung Kim,Jae-Sung Kim. (2020).Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes. The Korean Journal of Physiology & Pharmacology, 24 (3), 249-257

MLA

Yo-Seob Seo,In-A Cho,Tae-Hyeon Kim,Jae-Seek You,Ji-Su Oh,Gyeong-Je Lee,Do Kyung Kim,Jae-Sung Kim. "Oxysterol 25-hydroxycholesterol as a metabolic pathophysiological factors of osteoarthritis induces apoptosis in primary rat chondrocytes." The Korean Journal of Physiology & Pharmacology, 24.3(2020): 249-257

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