Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes

• 영문명: Modeling of Arrhythmogenic Automaticity Induced by Stretch in Rat Atrial Myocytes
• 발행기관: 대한생리학회-대한약리학회
• 저자명: Jae Boum Youm Chae Hun Leem Yin Hua Zhang Nari Kim Jin Han Yung E. Earm
• 간행물 정보: 『The Korean Journal of Physiology & Pharmacology』제12권 제5호, 267~274쪽, 전체 8쪽
• 주제분류: 의약학 > 의학일반
• 파일형태: PDF
• 발행일자: 2008.01.01

영문 초록

Since first discovered in chick skeletal muscles, stretch-activated channels (SACs) have been proposed as a probable mechano-transducer of the mechanical stimulus at the cellular level. Channel properties have been studied in both the single-channel and the whole-cell level. There is growing evidence to indicate that major stretch-induced changes in electrical activity are mediated by activation of these channels. We aimed to investigate the mechanism of stretch-induced automaticity by exploiting a recent mathematical model of rat atrial myocytes which had been established to reproduce cellular activities such as the action potential, Ca^2＋ transients, and contractile force. The incorporation of SACs into the mathematical model, based on experimental results, successfully reproduced the repetitive firing of spontaneous action potentials by stretch. The induced automaticity was composed of two phases. The early phase was driven by increased background conductance of voltage-gated Na^＋ channel, whereas the later phase was driven by the reverse-mode operation of Na^＋/Ca^2＋ exchange current secondary to the accumulation of Na^＋ and Ca^2＋ through SACs. These results of simulation successfully demonstrate how the SACs can induce automaticity in a single atrial myocyte which may act as a focus to initiate and maintain atrial fibrillation in concert with other arrhythmogenic changes in the heart.

키워드

Stretch Automaticity Atrial fibrillation Modeling