리스페리돈으로 무월경이 발생한 여자 정신분열병 환자의 우울, 불안, 삶의 질에 관한 연구

• 영문명: A Study on Depression, Anxiety and Quality of Life in Amenorrhea Schizophrenics Treated with Risperidone
• 발행기관: 대한신경정신의학회
• 저자명: 김연희 연규월 김미경 이혜진
• 간행물 정보: 『신경정신의학』제43권 제5호, 537~545쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2004.09.30

영문 초록

Objectives：Amenorrhea, one of the most common side effects of neuroleptics, has known to be associated with prolactin elevation. Hyperprolactinemia seriously affects mental health causing depression, anxiety or hostility, while also affecting physical health causing amenorrhea, galactorrhea or sexual dysfunction. The possible correlation between risperidone-induced amenorrhea and depression, anxiety and quality of life was evaluated in a cross-sectional open study. Methods：During a five-month period, WHO quality of life-BREF (WHOQOL), Beck depression inventory (BDI) and Statetrait anxiety inventory (STAI) were applied twice at two-month intervals for 30 patients with risperidone-induced amenorrhea and 22 patients without amenorrhea. Results：Amenorrhea group had significantly higher scores in BDI and STAI-state, while showing lower scores in the quality of life than control group. The total BDI and STAI-state scores were more negatively correlated with WHOQOL score in amenorrhea group. Conclusion：Patients with risperidone-induced amenorrhea rated themselves significantly more depressed and more anxious, and a lower quality of life compared to the control group. Clinicians should be more active in evaluating and treating hyperprolactinemic side effects such as amenorrhea, galactorrhea, depression and anxiety.

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키워드

Schizophrenia Risperidone Hyperprolactinemia Depression Anxiety Quality of life