ADH1B와 NQO2 유전자 다형성이 알코올 의존의 발병연령과 금단증상에 미치는 영향

• 영문명: The Effect of ADH1B and NQO2 Polymorphisms on the Age of Onset of Alcohol Dependence and Alcohol Withdrawal Symptoms
• 발행기관: 대한신경정신의학회
• 저자명: 이영식 한덕현 윤성구 최삼욱 조근호 서정석
• 간행물 정보: 『신경정신의학』제46권 제3호, 237~244쪽, 전체 8쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2007.05.30

영문 초록

Objectives：We hypothesized that polymorphisms of ADH1B and NQO2 could have an effect on the onset of alcohol dependence and withdrawal symptoms. Methods：PCR (polymerase chain reaction) and RFLP (restriction fragment length polymorphism) were used to analyze genetic polymorphisms of ADH1B and NQO2 in 194 male patients with alcohol dependence (AD) and 152 healthy comparisons. The AD were classified into the early and late onset groups with the onset age of 25. Alcohol withdrawal symptoms were measured by Clinical Institute Withdrawal Assessment for Alcohol Scale (CIWA-Ar). Results：1) Alcohol dehydrogenase 1B gene : There was no difference in genotype distribution between the patients group and the control group. However, the frequency of ADH1B*2 allele in late-onset alcohol dependence was higher compared to the early-onset group. 2) NRH-quinone oxidoreductase 2 (NQO2)：The patients group had higher frequency of D allele than the healthy comparisons. In patients group, the frequency of the D allele in the late-onset group was higher than the early-onset group. 3) CIWA-Ar scale : There was no difference in the CIWA-Ar scale between the genetic polymorphisms of ADH1B. However, the patients with D allele of NQO2 showed significantly higher scores in the CIWA-Ar scale than those with I/I allele. Conclusion：With current results, we suggested that ADH1B*2 and D allele of NQO2 may have a possible association with alcohol withdrawal symptoms and that they may play a protective role in the onset of alcohol dependence.

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키워드

Alcohol dependence Alcohol withdrawal ADH1B NQO2 Polymorphism