지연성 운동장애에 대한 Clonidine의 치료효과

• 영문명: The Efects of Clonidine Treatment on Tardive Dyskinesia
• 발행기관: 대한신경정신의학회
• 저자명: 이수경 김창현 오동열
• 간행물 정보: 『신경정신의학』제33권 제5호, 1174~1182쪽, 전체 9쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.09.30

영문 초록

We performed a double-blind placebo-controlled study to investigate the therapeutic effect of clonidine known as alpha 2 agonist on tardive dyskinesia. Twelve out of twenty two subjects were treated with Clonidine and ten subjects were treated with placebo over 8 weeks. They were assessed by Abnormal Involuntary Movement Scale(AIMS) and symptom changes was rated by Brief Psychiatric Rating Scale (BPRS) at baseline, 4 and 8 weeks of study. The results were as follows : 1) Total AIMS scores of 8th week improved significantly, compared with those of baseline in the both clonidine group(P<0.001) and placebo group(P<0.005). 2) Total AIMS scores and face, limbs, trunk scores of the clonidine administrated group were not significantly different from those of the placebo administrated group at baseline, 4th and 8th weeks of study. 3) Most common side effect was mild dizziness, which was controlled by lowering the dose, and this clonidine adminstration study did not show any statistically significant difference between clondine and placebo group in clinical efficacy, measuring by BPRS.

목차

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대상 및 방법

결 과

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참고문헌

키워드

Tardive dyskinesia Clonidine Norepineprine