P300에 나타난 정신분열병 환자의 인지적 결함 - 현실 변별 가설을 중심으로

• 영문명: Cognitive Deficits of the Schizophrenics in P300 — Reality Discrimination Hypothesis ᅳ
• 발행기관: 대한신경정신의학회
• 저자명: 김용석 박상학 김상훈
• 간행물 정보: 『신경정신의학』제33권 제5호, 1164~1173쪽, 전체 10쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 1994.09.30

영문 초록

To investigate cognitive deficits of schizophrenic patients, the authors examined ination test and the latency and amplitude of P300. Schizophrenic patients (15) and normal control subjects(l5) who were matched according to age, sex and education were categorized. A ll subjects were given 3 types of material set, which were made up of 10 opposite word pairs. And then they were tested for the recognition and the discrimination of memory sources. On next day, we collected the data of P300 amplitude and latency from them. The results were as follows : 1) There was no significant differences of recognition ability between both group. 2) Schizophrenic group had poorer signal sensitivity(d’ ). 3) There were no differences in discriminating what they had seen, but schizophrenic group showed lower capacity in discriminating what they had imagined and written. 4) Schizophrenic group had significantly delayed latency of P300, but the amplitude of P300 was not different in both group. 5) The correlation between reality-discrimination test and P300 amplitude and latency was not revealed. These data suggest that schizophrenic patients seen to be impaired in reality-discrimination ability which is one of the late information processing components.

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키워드

Schizophrenia Reality monitoring Event-related potential(P300) Reality discrimination hypothesis