활동기록기 기반 수면 지표를 이용한 우울증 예측

• 영문명: Prediction of Depression Using Actigraphy-Based Sleep Parameters
• 발행기관: 대한노인정신의학회
• 저자명: 홍지희(Ji Hui Hong) 추일한(Il Han Choo) 정재효(Jaehyo Jung) 김성재(Seong Jae Kim)
• 간행물 정보: 『노인정신의학』제29권 제2호, 79~83쪽, 전체 5쪽
• 주제분류: 의약학 > 정신과학
• 파일형태: PDF
• 발행일자: 2025.10.30

국문 초록

Objective: This study aimed to examine which actigraphy-based sleep parameters could effectively discriminate individuals with depression from those without depression, using receiver operating characteristic (ROC) analysis. Methods: We recruited outpatients aged 50 years or older from the Department of Psychiatry at Chosun University Hospital. Participants completed the Korean version of the Patient Health Questionnaire-9 (PHQ-9) and the Montgomery–Åsberg Depression Rating Scale. Those with PHQ-9 scores ≥10 were classified into the depression group (DG). Actigraphy (Actiwatch 2; Philips Respironics) was used at home for two consecutive days to assess sleep parameters, including bedtime (BT), time in bed (TIB), total sleep time, sleep onset latency, sleep efficiency, wake after sleep onset, and fragmentation index. Group comparisons were performed using the Mann–Whitney U test, and discriminative validity was assessed with ROC analysis. Results: Nineteen participants were included (DG: 13, non-depression group [NDG]: 6). Compared with the NDG, the DG showed significantly earlier BT and longer TIB (p<0.05). Among sleep parameters, TIB was identified as a significant discriminator of depression (area under the curve=0.80, cutoff=9 h 58 min, sensitivity=0.76, specificity=0.75). Conclusion: Individuals with depressive symptoms showed earlier bedtimes and significantly longer TIB compared to nondepressed participants. Prolonged TIB, exceeding two hours, may reflect reduced physical activity and serve as an objective marker for depression. Importantly, TIB was identified as a predictor of depression based on actigraphy-derived measures, suggesting potential clinical utility for early screening and intervention.

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키워드

우울증 액티그라피 수면-각성습관 침대에 머무는 시간 수면효율 Depression Actigraphy Sleep-wake habits Time in bed Sleep efficiency

참고문헌

• J Affect Disord
• J Psychiatr Res
• BMC Psychiatry
• Depress Anxiety
• JAMA Psychiatry
• J Gen Intern Med
• Br J Psychiatry
• Sleep
• Sleep Med Rev
• J Affect Disord
• Chronobiol Int
• JAMA
• Biol Psychiatry
• Psychiatry Clin Neurosci
• Sleep Med Rev