A형 간염의 자연항체와 예방접종을 통한 항체 생성률의 역가 비교분석

• 영문명: The Comparative Analysis of the Titer of Seroconversion Rate Through the Natural Antibody and Antibody after Vaccination of Hepatitis A
• 발행기관: 대한핵의학기술학회
• 저자명: 권원현(Won Hyun Kwon) 김경화(Kyung Hwa Kim) 조경아(Kyung A Cho) 문기춘(Ki Choon Moon) 김정인(Jung In Kim) 이인원(In Won Lee)
• 간행물 정보: 『핵의학기술』Vol.17 No.2, 95~100쪽, 전체 6쪽
• 주제분류: 의약학 > 방사선과학
• 파일형태: PDF
• 발행일자: 2013.11.30

영문 초록

Purpose: Since 2008, hepatitis A patients was rapidly increasing. So, Most of the health checkup examinees were interested in whether hepatitis A antibody was a lot. thereby The number of tests was increasing. In recent years, Antibody test results in the range of cut-off values were increased. According to the cause analysis, most examinees had a hepatitis A vaccine. This study was conducted to classify hepatitis A antibody as natural antibody and antibody after vaccination and compared the titer for seroconversion rate based on cut-off values. Materials and Methods: For a month in August 2012, First, We surveyed 185 health examinees and classified 119 health examinees who had acquired natural antibody. Second, for employees who were inoculated against hepatitis at our hospital, We classified into 53 primary inoculators and 59 secondary inculators. when the standard of cut-off value was 1, The seroconversion rate was compared the titer divided by 0.90-1.10 (±), 0.60-0,89 (1+), 0.30-0.59 (2+), 0.01-0.29 (3+) and we compared the titer for seroconversion rate by each manufacturer after vaccination. Results: When the standard of cut-off value was 1, the titer of 119 health examinees who had acquired natural antibody was 0.90-1.10 (±): 0%, 0.60-0.89 (1+): 0%, 0.30-0.59 (2+): 4.2%, 0.01-0.29 (3+): 96% and the titer of <0.60 (≧2+) was 100%. The titer of 53 primary inoculators was 0.90-1.10 (±): 59.1%, 0.60-0.89 (1+): 18.1%, 0.30-0.59 (2+): 18.1%, 0.01-0.29 (3+): 4.6% and the seroconversion rate was 45.3%. The titer of ≧0.60 (≦1+) was 77.3%. The titer of 59 secondary inoculators was 0.90-1.10 (±): 1.9%, 0.60-0.89 (1+): 15.4%, 0.30-0.59 (2+): 36.54%, 0.01-0.29 (3+): 46.2% and the seroconversion rate was 88.1%. The titer of <0.60 (≧2+) was 82.7%. When we compared the titer for seroconversion rate by each manufacturer after vaccination, the seroconversion rate of 53 primary inoculators was BNIBT: 20.8% (±: 24.5%), GB: 15.7% (±: 7.8%), RIAKEY: 94.3% (±: 3.8%), ROCHE: 83% (±: 0%), ABBOTT: 73.1% (±: 5.8%) and the seroconversion rate of 59 secondary inoculators was BNIBT : 86.4% (±: 1.7%), GB: 88.5% (±: 1.9%), RIAKEY: 100% (±: 0%), ROCHE: 98.3% (±: 0%), ABBOTT: 98.2% (±: 0%). Conclusion: The study show that the titer of natural immune antibodies is higher than the titer of vaccination and the titer of secondary inoculation is mainly higher than the titer of primary inoculation. Consequently, if we know the titer of hepatitis A antibodies, it will help to give resullt reports. And then, when we compared the titer and the seroconversion rate by each manufacturer, There was a very distinct difference. As the test subjects inoculate against hepatitis A (HAV), it is considered BNIBT, GB will occur false negative rate and RIAKEY, ROCHE, ABOTT will occur false positive rate.

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키워드

Natural immune antibody Vaccination Seroconversion rate Titer Cut-off