The Neurocognitive Function and Neuroimaging Characteristics between Age-Associated Memory Impairment and Mild Cognitive Impairment

• 발행기관: 대한임상노인학회
• 저자명: Ji-Hye Kim Ji-Won Lee
• 간행물 정보: 『대한임상노인학회지』대한임상노인의학회지 제20권 제1호, 18~25쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2019.06.30

영문 초록

Background: Age-associated memory impairment (AAMI) and mild cognitive impairment (MCI) were considered to have a positive correlation with early dementia status, reflecting the decline in objective cognitive function. Studies results exploring the character-istics of AAMI and MCI remain mixed. We investigated the characteristics of AAMI and MCI using neuroimaging and neurocognitive function in healthy Korean adults. Methods: This cross-sectional study analyzed a total of 14 participants who visited single health promotion center. AAMI and MCI was defined via questionnaires. Participants were classified into three groups based on neurocognitive status: normal, AAMI, MCI. We conducted either Kruskal-Wallis or chi-square test to compare the neuroimaging characteristics between three groups; Mann-Whitney U test was applied for the within-group analysis. Kruskal-Wallis test was used to investigate the neurocognitive function between three groups. Results: In the case of AAMI and MCI, there were partial metabolic decreases in various parts such as temporal lobe, frontal lobe, parietal lobe and cerebellum. Profound disparities in metabolic decrease in parietal lobe were observed among three groups (P=0.049). In the MMSE characteristics, MCI group showed marked deterioration in attention (P=0.030), and decreased in more various cognitive domains than AAMI group. Conclusion: The distinct neuroimaging characteristics were observed among three groups. The deficit of neurocognitive function was more prominent in attention in MCI group.

목차

INTRODUCTION

MATERIALS AND METHODS

RESULTS

DISCUSSION

키워드

Age-Related Memory Disorders Mild Cognitive Impairment Neuroimaging