비파엽 추출물의 안전성 검증과 표준화

• 영문명: Safety evaluation and standardization for Loquat (Eriobotrya japonica) leaves extract
• 발행기관: 전남대학교 생활과학연구소
• 저자명: 김용재(Yong jae Kim) 전우진(Woo jin Jun)
• 간행물 정보: 『生活科學硏究』生活科學硏究 第23輯, 71~83쪽, 전체 13쪽
• 주제분류: 자연과학 > 생활/식품과학
• 파일형태: PDF
• 발행일자: 2013.12.30

영문 초록

Loquat (Eriobotrya japonica) leaves collected from Jangheung Jeollanam-do was washed, cut, dried and extracted from 5% ethanol at 100 ℃ for 4 hours and freeze-dried to be used as the samples for the study. Safety evaluation was conducted under Korea Food and Drug Administration “Guideline for toxicity testing of pharmaceuticals according to Korea Technology Research(KTR), 2 weeks single oral dose toxicity test. From the results, there were no significant toxicological changes for the Loquat leaves extract (EJE) up to 2 weeks. when the Loquat leaves extract was orally administrated once at dose level of 2,000 mg/kg b.w. The quercetin, one of the ingredients for Loquat leaves, were analysed quantitatively to establish indicator with the use of HPLC. Quantitative result for the quercetin, 0.41 mg/g of raw materials were detected, and 0.69 mg/g of Loquat leaves extract was detected.

목차

Ⅰ. Introduction

Ⅱ. Materials and methods

Ⅲ. Results

Ⅳ. Conclusion

References

키워드

Loquat(Eriobotrya japonica) Safety foxicity HPLC Standardization