Oxidative Stress Levels in Aqueous Humor from High Myopic Patients

• 발행기관: 대한안과학회
• 저자명: Eun Bi Kim Ha Kyoung Kim Joon Young Hyon Won Ryang Wee Young Joo Shin
• 간행물 정보: 『The Korean Journal of Ophthalmology』Vol.30 No.3, 172~179쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2016.06.30

영문 초록

Purpose: To compare oxidative stress status in the aqueous humor of highly myopic eyes and control eyes. Methods: Aqueous humor samples were collected from 15 highly myopic eyes (high myopia group) and 23 cataractous eyes (control group) during cataract surgery. Central corneal thickness, corneal endothelial cell density, hexagonality of corneal endothelial cells, and cell area of corneal endothelial cells were measured using specular microscopy. Axial length was measured using ultrasound biometry. 8-Hydroxydeoxyguanosine (8-OHdG) and malondialdehyde levels were measured using enzyme-linked immunosorbent assay. Results: 8-OHdG level was lower in the aqueous humor of myopic patients than in that of control group (p = 0.014) and was positively correlated with central corneal thickness and negatively correlated with axial length (r = 0.511, p = 0.02; r = -0.382, p < 0.001). There was no correlation between 8-OHdG level and corneal endothelial cell density, hexagonality, or cell area. Malondialdehyde level did not show any correlation with any parameters evaluated. Conclusions: 8-OHdG might be a sensitive biomarker for evaluating oxidative stress status in the eye. Oxidative stress level was lower in the aqueous humor of highly myopic eyes compared to that in control eyes, which indicates lower metabolic activity in these eyes.

목차

Materials and Methods

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Conflict of Interest

Acknowledgements

References

키워드

8-Hydroxydeoxyguanosine Axial eye length Corneal pachymetry High myopia Malondialdehyde