p-Xylene의 디니트로화와 2,3-, 2,5- 및 2,6-dinitro-p-xylene의 효율적 분리

• 영문명: Dinitration of p-Xylene and Practical Separation of 2,3-, 2,5-, and 2,6-Dinitro-p-xylenes
• 발행기관: 대한약학회
• 저자명: 로 양(Yang Lu) 장영동(Yurng dong Jahng)
• 간행물 정보: 『약학회지』제62권 제5호(2018년), 362~365쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.10.30

영문 초록

A practical method for the preparation and separation of 2,3-, 2,5- and 2,6-dinitro-p-xylenes is described herein. The direct nitration of p-xylene with nitric acid (d 1.42) in the presence of sulfuric acid at 80oC afforded 2,3-, 2,5-, and 2,6- dinitro-p-xylenes in a ratio of 6.86:1:3.41, and the isomeric mixture could be readily separated by column chromatography on silica gel eluting with hexanes:EtOAc (19:1) as an eluent.

목차

Introduction

Experimental Methods

Results and Discussion

Conclusion

References

키워드

2,3-dinitro-p-xylene 2,5-dinitro-p-xylene 2,6-dinitro-p-xylene nitration p-xylene