Sceletium tortuosum의 구성성분 및 Mesembrine 관련 유도체에 관한 연구

• 영문명: Reviews on the Components of Sceletium tortuosum and Mesembrine Derivatives
• 발행기관: 대한약학회
• 저자명: 신나혜(Na Hye Shin) 이상협(Sang Hyup Lee)
• 간행물 정보: 『약학회지』제62권 제5호(2018년), 356~361쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2018.10.30

영문 초록

Sceletium tortuosum (family Aizoaceae) as an indigenous herb of South Africa is a succulent plant that has been used for medicinal purposes from the ancient times. Sceletium tortuosum preparations are known to be used as an ingredient for functional foods, beverages and supplements for promoting health and wellness in healthy people and in sick people (stress, anxiety and depression). Main components of the extracts were classified according to the structural features. Mesembrine and mesembrenone are the two main pharmacologically active alkaloids in the extracts. Importantly, mesembrine has drawn our attention due to the concise structure, broad spectrum, and low toxicities. The general aspects of biological and medicinal properties, and structural features and total synthesis were described. In particular, mesembrine has been known to exhibit antidepressant, anticonvulsant, anxiolytic, sedative, and sleep aid activities without severe side effects. It is believed that the potential of mesembrine and its derivatives is recognized.

목차

서 론(Introduction)

결 론(Conclusion)

감사의 말씀(Acknowledgments)

References

키워드

Sceletium tortuosum mesembrine mesembrenone antidepressant