B16 흑색종세포에서 아라키돈산 유발 활성산소종의 멜라닌 합성 촉진 효과

• 영문명: Effects of Reactive Oxygen Species Induced by Arachidonic Acid on the Stimulation of Melanin Synthesis in B16 Melanoma Cells
• 발행기관: 대한약학회
• 저자명: 이용수(Yong Soo Lee)
• 간행물 정보: 『약학회지』제61권 제5호(2017년), 248~253쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.10.30

영문 초록

Arachidonic acid (AA) increased production of reactive oxygen species (ROS) in B16 melanoma cells. The AA-induced ROS production and melanogenesis were significantly blocked by treatment with DPI and DIOA, specific inhibitors of NADPH oxidase and K⁺₋Cl⁻₋cotransport (KCC), respectively. These results suggest that ROS production by the KCC-linked activation of the NADPH oxidase may play a role in the AA-induced melanogenesis.

목차

Abstract

실험 방법(Experimental methods)

실험 결과 및 고찰(Results and discussion)

결론(Conclusion)

감사의 말씀(Acknowledgement)

References

키워드

arachidonic acid melanogenesis reactive oxygen species NADPH oxidase K+-Cl--cotransport B16 melanoma cell