새로운 메틸 3,4-디알킬카보닐옥시-5-메톡시벤조에이트 유도체의 합성 및 항산화와 세포증식억제 작용

• 영문명: Antioxidant, Antiproliferative Activity and Synthesis of Novel Methyl 3,4- Dialkylcarbonyloxy-5-methoxybenzoate Derivatives
• 발행기관: 대한약학회
• 저자명: 김채원(Chae won Kim) 신다혜(Da Hae Shin) 정하숙(Ha sook Jung) 박명숙(Myung Sook Park)
• 간행물 정보: 『약학회지』제61권 제5호(2017년), 260~266쪽, 전체 7쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2017.10.30

영문 초록

The antiproliferative and antioxidative properties of novel polyphenolic acid derivatives, structurally related with the natural model gallic acids, have been tested in cancer cell lines (MCF-7, Hep3B, RKO) and lipid peroxidation. A new series of methyl 3,4-dialkylcarbonyloxy-5-methoxybenzoate 4a~4e was synthesized by acylation from O-methyl gallicin 3 for search of bioactive compounds. The structures of the synthetic compounds were characterized using ¹H, ¹³C NMR and HRMS spectroscopy. Two target compounds (4c, 4d) showed higher potency than propyl gallicin or drumstick-tree (Moringa oleifera Lam.) extracts for inhibiting the growth of cancer cell lines (MCF-7, Hep3B, RKO). The antioxidative properties of 4b among synthetic compounds was similar to the antioxidant propyl gallate and α-tocopherol.

목차

Abstract

실험방법(Experimental Methods)

결과 및 고찰(Results and Discussion)

결론(Conclusion)

References

키워드

Methyl gallicins Methyl 3,4-dialkylcarbonyloxy-5-methoxybenzoates Acylation Antioxidant Antiproliferative activity