n-3 고도불포화 지방상 수준을 달리한 식이가 Streptozotocin으로 유발된 당뇨쥐의 대사에 미치는 영향

• 영문명: Dose-Response Effects of n-3 Polyunsaturated Fatty Acids Supplement on the Metabolism of Streptozotocin-Induced Diabetic Rats
• 발행기관: 한국응용과학기술학회 (구.한국유화학회)
• 저자명: 김태숙(Kim Tae Suk) 최은진(Choi Eun Jin) 조용계(Joh Yong Gae)
• 간행물 정보: 『한국응용과학기술학회지』한국유화학회지 제9권 제1호, 15~23쪽, 전체 9쪽
• 주제분류: 공학 > 화학공학
• 파일형태: PDF
• 발행일자: 1992.05.30

영문 초록

This study was aimed to observe dose-response effects of squid liver oil enriched in n-3 polyunsaturated fatty acids(n-3 PUFA) on the metabolism of streptozotocin(STZ)-induced diabetic rats. In this experiment, 24 STZ-induced diabetic male rats of Sprague Dawley strain were divided into 4 groups and fed for 4 weeks with basal diet(O%), 33%, 67% and 100% squid liver oil(SLO) of total fat content, and 6 normal rats were fed with 0% SLO diet at the same time. The results obtained were as follows : 1. Rat group fed with 33% SLO diet showed the least body weight loss and changes in blood glucose, while ones of 100% SLO diet showed the highest level. 2. Serum total protein and ratio of albumin to globulin of all the groups were below the standard level, but did not show significantly different among diet groups. 3. Serum creatinine concentration of all the groups were stayed whthin normal range, but BUN were 3 to 4 times higher than normal rats. BUN concentration of rats fed with 0% and 33% SLO diet was significantly lower than those of others. 4. Total-cholesterol level of serum increased in all the groups except 33% SLO diet, but since HDL-chol. levels and TG concentration went up with an incerase of SLO in the diets, the ratio of HDL-chol. to total-chol. of rats fed with 67% and 100% SLO diet showed higher than those with 0% and 33% SLO, and TG concentration of rats fed with 67% and 100% SLO diet decreased significantly.

목차

ABSTRACT

I. 서론

II. 실험재료 및 방법

III. 실험결과 및 고찰

IV. 결론

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