A rare case of osteonecrosis of the jaw related to imatinib

• 발행기관: 대한구강악안면외과학회
• 저자명: Massimo Viviano Marco Rossi Serena Cocca
• 간행물 정보: 『대한구강악안면외과학회지』대한구강악안면외과학회지 제43권 제2호, 120~124쪽, 전체 5쪽
• 주제분류: 의약학 > 내과학
• 파일형태: PDF
• 발행일자: 2017.04.30

영문 초록

Osteonecrosis of the jaw (ONJ) is commonly described as an adverse effect of the use of bisphosphonates. A few cases of ONJ associated with tyrosine kinase inhibitors (sunitinib, imatinib) have been reported in the literature and usually they occurred in patients simultaneously treated with bisphosphonates. We report an atypical case of ONJ related only to imatinib. A 72-year-old male patient was treated with imatinib for metastases from gastrointestinal stromal tumors (GISTs). The patient developed ONJ after 22 months of imatinib only therapy. During his whole life, the patient had never been treated with bisphosphonates or radiotherapy. Microscope examination of the tissues confirmed the clinical diagnosis of diffuse osteonecrosis and showed absence of neoplastic cells. Thus, secondary localisations from GISTs were ruled out. Osteonecrosis of the lower jaw appeared 22 months after initial and exclusive therapy with imatinib. Therefore, imatinib monotherapy can induce ONJ in patients that have never been treated with bisphosphonates or radiotherapy.

목차

Abstract

I. Introduction

II. Case Report

III. Discussion

References

키워드

Imatinib mesylate Osteonecrosis Oral surgery Gastrointestinal stromal tumors Bone remodeling