프탈레이트류와 그 대체물질의 내분비계 교란독성: 에스트로겐성과 안드로겐성을 중심으로

• 영문명: Estrogenic and Androgenic Potential of Phthalates and Their Alternatives
• 발행기관: 한국환경보건학회
• 저자명: Bareum Kwon Kyunghee Ji
• 간행물 정보: 『한국환경보건학회지』제42권 제3호, 169~188쪽, 전체 20쪽
• 주제분류: 공학 > 환경공학
• 파일형태: PDF
• 발행일자: 2016.06.30

영문 초록

Objectives: Although information on the toxicity of phthalate diesters is readily available, little is known about phthalate alternatives. The present article provides a summary of available information on the toxicity of phthalate diesters and their alternatives, with a special focus on estrogenicity and androgenicity. Methods: We collected a battery of in vitro and in vivo assay data from the literature to assess the estrogenicity/ anti-estrogenicity and androgenicity/anti-androgenicity of 15 phthalate diesters and 21 phthalate alternatives. Results: A number of in vitro studies show that certain phthalate diesters can bind to estrogen receptors and have a weak estrogenic potential. However, this potential was not seen in in vivo studies. Phthalate diesters produced anti-androgenic effects in animals by reducing testosterone production. Among them, di-(2-ethyl-hexyl) phthalate (DEHP) was the most potent. While almost all phthalate alternatives have a lower toxic potential than does DEHP, evidence of reproductive toxicity and estrogenic potential were found in several substances. Conclusion: Significant data gaps exist for phthalate alternatives regarding reproductive endocrine disruption, requiring further investigation.

목차

I. Introduction

II. Methods

III. Results and Discussion

V. Conclusion

키워드

Alternatives anti-androgenicity endocrine disruption estrogenicity phthalate