Significant fibrosis after radiation therapy in a patient with Marfan syndrome

• 발행기관: 대한방사선종양학회
• 저자명: Eva M. Suarez MD Rebecca J. Knackstedt BS Joseph M. Jenrette MD
• 간행물 정보: 『대한방사선종양학회지』제32권 제3호, 208~212쪽, 전체 5쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2014.09.30

영문 초록

Marfan syndrome is one of the collagen vascular diseases that theoretically predisposes patients to excessive radiation-induced fibrosis yet there is minimal published literature regarding this clinical scenario. We present a patient with a history of Marfan syndrome requiring radiation for a diagnosis of a right brachial plexus malignant nerve sheath tumor. It has been suggested that plasma transforming growth factor beta 1 (TGF-β1) can be monitored as a predictor of subsequent fibrosis in this population of high risk patients. We therefore monitored the patient’s TGF-β1 level during and after treatment. Despite maintaining stable levels of plasma TGF-β1, our patient still developed extensive fibrosis resulting in impaired range of motion. Our case reports presents a review of the literature of patients with Marfan syndrome requiring radiation therapy and the limitations of serum markers on predicting long-term toxicity.

목차

1. Introduction

2. Case Report

3. Discussion

4. Conflict of Interest

5. References

키워드

Marfan syndrome Radiation therapy Transforming growth factor beta1 Fibrosis