Outcome of postoperative radiotherapy following radical prostatectomy: a single institutional experience

• 발행기관: 대한방사선종양학회
• 저자명: Sea-Won Lee MD Tae-Kon Hwang MD Sung-Hoo Hong MD Ji-Youl Lee MD Mi Joo Chung MD Song Mi Jeong MD Sung Hwan Kim MD Jong Hoon Lee MD Hong Seok Jang MD Sei Chul Yoon MD
• 간행물 정보: 『대한방사선종양학회지』제32권 제3호, 138~146쪽, 전체 9쪽
• 주제분류: 의약학 > 종양학
• 파일형태: PDF
• 발행일자: 2014.09.30

영문 초록

Purpose: This single institutional study is aimed to observe the outcome of patients who received postoperative radiotherapy after radical prostatectomy. Materials and Methods: A total of 59 men with histologically identified prostate adenocarcinoma who had received postoperative radiation after radical prostatectomy from August 2005 to July 2011 in Seoul St. Mary’s Hospital of the Catholic University of Korea, was included. They received 45–50 Gy to the pelvis and boost on the prostate bed was given up to total dose of 63–72 Gy (median, 64.8 Gy) in conventional fractionation. The proportion of patients given hormonal therapy and the pattern in which it was given were analyzed. Primary endpoint was biochemical relapse-free survival (bRFS) after radiotherapy completion. Secondary endpoint was overall survival (OS). Biochemical relapse was defined as a prostate-specific antigen level above 0.2 ng/mL. Results: After median follow-up of 53 months (range, 0 to 104 months), the 5-year bRFS of all patients was estimated 80.4%. The 5-year OS was estimated 96.6%. Patients who were given androgen deprivation therapy had a 5-year bRFS of 95.1% while the ones who were not given any had that of 40.0% (p < 0.01). However, the statistical significance in survival difference did not persist in multivariate analysis. The 3-year actuarial grade 3 chronic toxicity was 1.7% and no grade 3 acute toxicity was observed. Conclusion: The biochemical and toxicity outcome of post-radical prostatectomy radiotherapy in our institution is favorable and comparable to those of other studies.

목차

1. Introduction

2. Materials and Methods

3. Results

4. Discussion and Conclusion

5. Conflict of Interest

6. References

키워드

Prostatic neoplasmsr Radiation Prostatectomy Androgen deprivation therapy