학술논문
Effects of total body irradiation-based conditioning on allogeneic stem cell transplantation for pediatric acute leukemia: a single-institution study
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- 영문명
- 발행기관
- 대한방사선종양학회
- 저자명
- Jongmoo Park MD PhD Eun Kyung Choi MD Jong Hoon Kim MD Sang-wook Lee MD PhD Si Yeol Song MD PhD Sang Min Yoon MD Young Seok Kim MD PhD Su Ssan Kim MD PhD Jin-hong Park MD PhD Jaehyeon Park MD Seung Do Ahn MD PhD
- 간행물 정보
- 『대한방사선종양학회지』제32권 제3호, 198~207쪽, 전체 10쪽
- 주제분류
- 의약학 > 종양학
- 파일형태
- 발행일자
- 2014.09.30
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국문 초록
영문 초록
Purpose: To evaluate the effects of total body irradiation (TBI), as a conditioning regimen prior to allogeneic stem cell transplantation (allo-SCT), in pediatric acute leukemia patients. Materials and Methods: From January 2001 to December 2011, 28 patients, aged less than 18 years, were treated with TBI-based conditioning for allo-SCT in our institution. Of the 28 patients, 21 patients were diagnosed with acute lymphoblastic leukemia (ALL, 75%) and 7 were diagnosed with acute myeloid leukemia (AML, 25%). TBI was completed 4 days or 1 day before stem cell infusion. Patients underwent radiation therapy with bilateral parallel opposing fields and 6-MV X-rays. The Kaplan-Meier method was used to calculate survival outcomes. Results: The 2-year event-free survival and overall survival rates were 66% and 56%, respectively (71.4% and 60.0% in AML patients vs. 64.3% and 52.4% in ALL patients, respectively). Treatment related mortality rate were 25%. Acute and chronic graft-versus-host disease was a major complication; other complications included endocrine dysfunction and pulmonary complications. Common complications from TBI were nausea (89%) and cataracts (7.1%). Conclusion: The efficacy and toxicity data in this study of TBI-based conditioning to pediatric acute leukemia patients were comparable with previous studies. However, clinicians need to focus on the acute and chronic complications related to allo-SCT.
목차
1. Introduction
2. Materials and Methods
3. Results
4. Discussion and Conclusion
5. Conflict of Interest
6. References
키워드
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