홍삼 Ginsenoside의 Cytochrome P450 저해 활성 평가

• 영문명: In vitro Assessment of Cytochrome P450 Inhibition by Red Ginseng Ginsenosides
• 발행기관: 대한약학회
• 저자명: 류창선(Chang Seon Ryu) 신장현(Jang Hyun Shin) 신병찬(Byoung Chan Shin) 심재한(Jae Han Sim) 양현동(Hyeon Dong Yang) 이성우(Sung Woo Lee) 김봉희(Bong-Hee Kim)
• 간행물 정보: 『약학회지』제59권 제2호 (2015년), 49~54쪽, 전체 6쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.04.30

영문 초록

In the present study we evaluated comparative herb-drug interaction potential of red ginseng total powder, ginsenoside Rg1, and Rb1 by inhibition of CYP isoforms including CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and CYP3A4 using pooled human liver microsomes (HLMs). As measured by liquid chromatography-electrospray ionization tandem mass spectrometry, red ginseng total powder inhibited significantly activities of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP2E1 and testosterone 6-beta hydroxylation by CYP3A4, but the IC50 values were higher than 556 μg/ml. Activities of CYP2B6, CYP2C9, CYP2D6 and CYP3A4 were inhibited by ginsenoside Rb1. Also, activities of CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6 and testosterone 6-beta hydroxylation by CYP3A4 were inhibited by ginsenoside Rg1. The IC50 values of ginsenoside Rb1 and Rg1 were higher than 200 μg/ml. Based on IC50 values against CYP isoforms, ginsenosides-drug interactions by CYP inhibition may be very low in clinical situations.

키워드

cytochrome P450 red ginseng ginsenoside drug-drug interaction