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• 영문명: Concise Synthesis of Flurbiprofen via Palladium-Catalyzed Cross-Coupling Reactions
• 발행기관: 대한약학회
• 저자명: 한영택(Young Taek Han)
• 간행물 정보: 『약학회지』제59권 제2호 (2015년), 66~69쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.04.30

영문 초록

A concise synthesis of flurbiprofen, a member of the non-steroidal anti-inflammatory 2-arylpropionic acids, has been accomplished. The key feature of this synthesis involves successive palladium-catalyzed cross coupling reactions. In particular, a 2-arylacylate intermediate, which easily converted to the key 2-arylpropionic acid scaffold, was afforded by a versatile palladium-catalyzed cross coupling reaction between diazopropanate and bisphenylboronic acid. This synthetic procedure would facilitate synthesis of the flurbiprofen and anti-inflammatory 2-arylpropionic acid derivatives.

키워드

flurbiprofen synthesis 2-arylpropionic acid palladium catalyzed cross-coupling diazo compound