N-아릴-3-페닐프로판아마이드 유도체 합성 및 NF-κB 저해 활성

• 영문명: Synthesis and NF-κB Inhibitory Activities of N-Substituted-aryl-3-phenylpropanamide Derivatives
• 발행기관: 대한약학회
• 저자명: 최민호(Minho Choi) 김영수(Youngsoo Kim) 정재경(Jae-Kyung Jung) 이희순(Heesoon Lee)
• 간행물 정보: 『약학회지』제59권 제2호 (2015년), 55~58쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2015.04.30

영문 초록

A series of N-substitutedaryl-3-phenylpropanamide derivatives were synthesized and their inhibitory activities on LPS-induced NF-κB transcriptional activity on RAW 264.7 cells were evaluated. Cl substituted derivatives (1e, 1f) have shown more potent activities than parent hit compound KL-1156.

키워드

NF-κB KL-1156 N-substitutedaryl-3-phenylpropanamide derivatives