천연마테차 물추출물의 고지방식이 비만쥐의 체중과 생화학적 변화에 미치는 영향

• 영문명: The Effect of Natural Mate Tea Extract on the Body Weight and Biochemical Biomarker in High Fat Diet-Obese(ob/ob) Mice
• 발행기관: 대한약학회
• 저자명: 김상태(Sang Tae Kim) 황초원(Cho Won Hwang) 김영균(Young Kyoon Kim)
• 간행물 정보: 『약학회지』제56권 제1호 (2012년), 1~8쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2012.02.28

영문 초록

In this study, we investigated the anti-obese activity of sevennight extract in high fat diet-ob/ob C57BL/6J mice by oral administered for 1 weeks. Mate water extract (MATEWi) was found to lower whole body and epididymal adipose tissue weights and lowered plasma levels of triglyceride (TG) and total cholesterol (TC), HDL and LDL, compared to those in high fat fed ob/ob group. These results suggest that Mate extract ameliorates obesity through activation of lipogenic enzymes and FA oxidation resulting from phosphorylation of AKT and GSK-3β, and could be developed as a potential therapeutic agent for obese mices.

키워드

ob/ob fat free fatty acid HDL lipogenic and lipolytic enzymes