큰 망막색소상피 박리를 동반한 맥락막혈관신생에서의 복합치료

• 영문명: Combination Treatment for Choroidal Neovascularization Associated With Large Retinal Pigment Epithelial Detachment
• 발행기관: 대한안과학회
• 저자명: 류정완 정재훈 이원기,Jung-Wan Ryu, MD, Jae-Hun Jung, MD, Won-Ki Lee, MD
• 간행물 정보: 『대한안과학회지』Ophthalmological Society,volume50,number6, 877~886쪽, 전체 10쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 2009.06.15

영문 초록

Purpose: To evaluate the efficacy of the combination therapy of intravitreal bevacizumab injection and photodynamic therapy in neovascular age-related macular degeneration associated with large retinal pigment epithelial detachment. Methods: A total of 13 eyes were reviewed, with 9 eyes diagnosed with definite choroidal neovascularization (CNV) and 4 eyes diagnosed with CNV or polypoidal choroidal vasculopathy (PCV) becausethe exact type could not be determined. Photodynamic therapy was performed within 1 week after bevacizumab injection according to indocyanine green angiography (ICGA). Additional bevacizumab injections were performed within a 4 to 6 week interval. Additional photodynamic therapy was performed within 4 months. Results: The visual acuity on final examination had improved in 3 eyes (23.1%), was maintained in 7 eyes (53.8%), and decreased in 3 eyes (23.1%). The change of the PED before and after treatment showed regression in 5 eyes (38.5%), recurrence after regression in 2 eyes (15.4%), persistence in 4 eyes (30.8%), and retinal pigment epithelial tear in 2 eyes (15.4%). The maintained or improved visual acuity rate was 66.7% (6/9) and 100% (4/4) in the CNV and CNV or PCV group, respectively. Conclusions: The combination therapy in neovascular age-related macular degenerationassociated with large retinal pigment epithelial detachment is a viable alternative treatment in the stabilization and improvement of vision. However, further studies with long-term follow up and controlled studies with anti-vascular endothelial growth factor antibody monotherapy are required. J Korean Ophthalmol Soc 2009;50(6):877-886

키워드

Bevacizumab, Choroidal neovascularization, Combination treatment, Photodynamic therapy, Retinal pigment epithelial detachment