신합성 플로로퀴놀론계 항생물질인 DWP20367의 In vitro 항균효과

• 영문명: In vitro Antibacterial Activities of Novel Fluoroquinolone DWP20367
• 발행기관: 대한약학회
• 저자명: 김지연(Ji Yeon Kim) 최문정(Moon Jung Choi) 한승희(Seung Hee Han) 심점순(Jeom Soon Shim) 정연의(Yeon Eui Jung) 손호정(Ho Jung Son) 이재욱(Jae Wook Lee) 유영효(Young Hyo Yu) 박명환(Myung Hwan Park)
• 간행물 정보: 『약학회지』제41권 제2호 (1997년), 225~232쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.04.30

영문 초록

The in vitro antibacterial activity of DWP20367 (1-Cyclopropyl-6-fluoro-8-chloro-7-(2,7-diazabicyclo[3,3,0]oct-4-ene-7-yl)-1,4-dihydro-4-oxoquinoline-3-carboxylic acid), a new broad-spectrum fluoroquinolone, was compared with those of ciprofloxacin (CPFX), sparfloxacin (SPFX) and ofloxacin (OFLX). DWP20367 was showed antibacterial activity much higher than CPFX, SPFX and OFLK against gram-positive bacteria, while it was slightly more superior to quinolones against gram-negative bacteria. DWP20367 was particularly effective against MRSA, and its MlC90 against clinical isolates of methicillin-susceptible S. aureus, low methicillin-resistant S. aureus and high methicillin-resistant S. aureus were 0.098, 0.781 and 1.563 micro g/ml, respectively. Against S. pneumoniae, MIC90 of DWP20367 was 2- to 8-fold higher than those of CPFX. With a view of MIC90, DWP20367 showed slightly more potent activity against P. aeruginosa and E. coli isolates than the control quinolones. DWP20367 activity was not affected by inoculum size and medium pH. But addition of Mg2+, Ca2+ or horse serum (25%) decreased its antibacterial activity. DWP20367 was showed rapidly bactericidal activity within 2 to 4 h, and regrowth was not observed even after 24 h incubation at concentrations near the 4-fold of MIC.

키워드

DWP20367 MIC pH effect Serum effect Inoculum size effect Metal ion effect Killing curve.