폴록사머-폴리아크릴산 IPNs의 약물 조절 방출

• 영문명: Drug Release Control of Poloxamer-Poly(acrylic acid) Interpenetrating Polymer Networks
• 발행기관: 대한약학회
• 저자명: 변은정(Eun Jung Byun) 박주애(Joo Ae Park) 이승진(Seung Jin Lee) 김길수(Kil Soo Kim)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 22~29쪽, 전체 8쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

Poloxamer-poly (acrylic acid) (PAA) interpenetrating polymer networks (IPNs) were prepared via matrix polymerization of acrylic acid with poloxamer prepolymer. The equilibrium swelling of poloxamer/PAA IPNs was determined in various pH medium. The swelling of poloxamer/PAA IPNs was more affected by pH difference compared with the swelling of homo PAA gel due to protonation and deprotonation of the PAA network, followed by reversible formation and dissociation of the interpolymer complex due to hydrogen bonding between acidic hydrogens and ether oxygens. Nonionic/anionic/cationic drugs were incorporated into IPN matriceds as a model drug and their release behavior was studied. Nonionic, drug revealed release patterns depending solely on pH dependent swelling kinetics. In contrast, the release of ionic drugs was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics.

키워드

Interpenetrating polymer network poloxamer poly(acrylic acid) drug release control pH-dependent swelling.