항암제로서의 (+/-)-3-데옥시제리쿠드라닌 A의 설계 및 합성

• 영문명: Design and Synthesis of (+/-)-3-Deoxygericudranin A as an Antitumour Agent
• 발행기관: 대한약학회
• 저자명: 최윤정(Yoon Jung Choi) 심필종(Pil Jong Shim) 김희두(Hee Doo Kim)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 14~17쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

(+/-)-3 Deoxygericudranin A was designed and synthesized for the development of novel antitumour agent and for the elucidation of the effect of 3-hydroxyl group in gericudranin A on antitumour activity. 2,4.6-Trihydroxyacetophenone was converted to 3-deoxygericudranin A in 5 steps via sequential protection, aldol condensation, Michael tvpe-cyclization, regioselective, C-benzylation and deprotection.

키워드

3-deoxygericiidranin A gericudranin A antitumour activity synthesis. Michael type cyclization regioselective C-benzylation.