트로판 알칼로이드의 아자비시크로[3.2.1]옥탄 골격합성

• 영문명: Synthesis of Azabicyclo[3.2.1]octane Skeleton of Tropane Alkaloid
• 발행기관: 대한약학회
• 저자명: 서영거(Young Ger Suh) 최영기(Young Gi Choi) 정재경(Jae Kyung Jung) 민경훈(Kyung Hoon Min)
• 간행물 정보: 『약학회지』제41권 제1호 (1997년), 18~21쪽, 전체 4쪽
• 주제분류: 의약학 > 기타의약학
• 파일형태: PDF
• 발행일자: 1997.01.31

영문 초록

Synthesis of an optically active azabicyclo[3.2.1]octane skeleton as a backbone of the tropane alkaloids has been achieved by employing intramolecular Mannich reaction. Utilization of (R)-alpha-methylbenzylamine as a chiral auxiliary provided an excellent cyclization of amino dioxolane precursor. However, this auxiliary did not afford high asymmertic induction for the preparation of the optically active cyclization precursor.

키워드

Tropane alkaloid intramolecular Mannich reaction azabicyclo[3.2.1] octane.